WESU operates 24 hours a day. Until 2004, WESU's format had been entirely freeform, with DJs and student staff having complete freedom to program what they will. The university had announced its intent to seek an affiliation with National Public Radio, and to drastically change the station's format. Douglas Bennet, then President of the University, was a former president of NPR. The station now broadcasts an NPR feed from WSHU, the college station of Sacred Heart University, for several hours a day. For the remainder of the broadcast day, WESU continues to operate as a free-form station.
WESU broadcasts at 88.1 MHz FM, with 6,000 Watts ERP, circular polarization, from the top of Wesleyan University's Exley Science Center in Middletown, Connecticut. The programming is a mix of freeform, National Public Radio and Pacifica Radio Network Programs. WESU also broadcasts Democracy Now! and Free Speech Radio News from the Pacifica Radio Network. The radio station was shown on the show "How I Met Your Mother". At the end of the episode "The Possimpible", Ted Mosby (Josh Radnor) is deleting his work experience from the radio station from his resume.
WESU Magazine is a music and radio themed publication created by Wesleyan students, Middletown community members, and WESU DJs. This magazine creates a look for freeform radio by placing works into print. It is a method for creating independent media that promotes the value of a non-commercial college radio station.